The alfapump® system is not currently approved in the United States or Canada. In the United States and Canada, the alfapump® system is currently under clinical investigation (POSEIDON Study) and is being studied in adult patients with refractory or recurrent ascites due to cirrhosis. For more information regarding the POSEIDON clinical study see www.poseidonstudy.com.
The DSR® therapy is still in development and it should be noted that any statements regarding safety and efficacy arise from ongoing pre-clinical and clinical investigations which have yet to be completed.
The DSR® therapy is not currently approved for clinical research in the United States or Canada. There is no link between the DSR® therapy and ongoing investigations with the alfapump® system in Europe.


Ongoing studies
Published & Presented studies
Other alfapump publications
Liver and malignant ascites

This is a prospective, multi-centre, open-label, randomised, health-economic study in France to evaluate the cost utility of the alfapump® versus standard of care in 90 patients with liver refractory ascites, 60 patients not waiting for liver transplant and 30 patients as bridge to transplant, over 12 months. The goal of the study is to support French reimbursement. The study is funded by the French government and being conducted and sponsored by leading French clinicians (NCT03506893).

Liver and malignant ascites

Retrospective, multi-centre, open-label study in Europe to assess the performance and safety of the alfapump® in 17 patients with malignant ascites (NCT03200106).

Abstract | Poster by Fotopoulou et al., IGCS, 2018


Prospective, multi-centre, open-label, single-arm study in North America to assess the safety and efficacy of the alfapump® in 30 patients with liver recurrent or refractory ascites not eligible for TIPS (NCT02400164).

Abstract | Poster par Wong et al., AASLD, 2017
Poster by Wong et al., AASLD, 2018

Retrospective, single-centre study at Hannover Medical School to investigate the alfapump® as an alternative for LVP in 21 patients with liver refractory ascites with a contraindication for TIPS or liver transplant.

Solbach et al., European Journal of Gasteroenterology & Hepatology, 2018

Prospective, multi-centre, open-label, observational study in Europe designed to follow 100 patients with liver refractory ascites with a contra-indication to TIPS and therefore treated with an alfapump® for up to 24 months (NCT01532427).

Stirnimann et al., Alimentary Pharmacology & Therapeutics, 2017 (data on the first 56 patients)
Editorial by Macdonald and Jalan, Alimentary Pharmacology & Therapeutics, 2017

Prospective, multi-centre, open-label, randomised and controlled study in Europe of the alfapump® versus LVP standard of care in 58 patients with liver refractory ascites (NCT01528410).

Bureau et al., Journal of Hepatology, 2017
Stepanova et al., Quality of Life Research, 2018

Prospective, multi-centre, open-label, uncontrolled study in Europe to assess the safety and performance of the alfapump® in 40 patients with liver refractory ascites and diuretic resistance (NCT01030185).

Bellot et al., Journal of Hepatology, 2013

Volume overload due to heart failure

First-in-human single dose DSR proof of concept study to assess safety, tolerability and impact of direct sodium removal therapy in 10 patients receiving peritoneal dialysis (PD). Results selected for late-breaking abstract session at Heart Failure 2019.

Presentation by Dr. Testani at Heart Failure 2019
Webcast by Sequana Medical management and Dr. Testani on 27 May 2019


Single dose, single arm preclinical proof of concept study to assess impact of direct sodium removal therapy in 15 healthy pigs and 5 pigs with experimentally induced heart failure via tamponade.

Poster by Testani et al., HFSA, 2018

Case study of treatment of a patient with malignant ascites using the alfapump®.

Storni et al., The American Journal of Gastroenterology, 2018

Review of the available data about patient selection, efficacy and safety of the alfapump® and recommendations for the management of patients treated with the alfapump®.

Stirnimann et al., Therapeutics Advances in Gastroenterology, 2017

We would like to use cookies to better understand your use of this website. This enables us to improve your future experience on our website. Detailed information about the use of cookies on this website and how you can manage or withdraw your consent at any time can be found in our. Privacy & Cookie Policy

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.