{"id":5158,"date":"2018-09-17T09:50:22","date_gmt":"2018-09-17T07:50:22","guid":{"rendered":"https:\/\/www.sequanamedical.com\/sequana-medical-announces-presentation-pre-clinical-proof-concept-results-direct-sodium-removal-dsr-therapy-management-volume-overload-heart-failure-annual-scientif\/"},"modified":"2022-07-07T14:23:11","modified_gmt":"2022-07-07T12:23:11","slug":"sequana-medical-announces-presentation-pre-clinical-proof-concept-results-direct-sodium-removal-dsr-therapy-management-volume-overload-heart-failure-annual-scientif","status":"publish","type":"post","link":"https:\/\/www.sequanamedical.com\/nl\/persberichten\/sequana-medical-announces-presentation-pre-clinical-proof-concept-results-direct-sodium-removal-dsr-therapy-management-volume-overload-heart-failure-annual-scientif\/","title":{"rendered":"Sequana Medical announces presentation of pre-clinical proof of concept results of its Direct Sodium Removal (DSR) therapy for the management of volume overload in heart failure at the Annual Scientific Meeting of the Heart Failure Society of America (HFSA)"},"content":{"rendered":"<p><strong>Zurich, SWITZERLAND \u2013 17 September 2018 \u2013 Sequana Medical AG (\u201cSequana Medical\u201d)<\/strong>, a commercial stage medical device company focused on the development of innovative treatment<br \/>\nsolutions for the management of liver disease, heart failure, malignant ascites and other fluid imbalance disorders, announces today positive findings from its Direct Sodium Removal (\u201cDSR\u201d) therapy proof of<br \/>\nconcept study in pigs.<\/p>\n<p>Sequana Medical\u2019s proprietary DSR therapy is a novel approach to the management of volume overload in heart failure, a major clinical problem and a significant burden on healthcare systems. The body\u2019s<br \/>\nresponse to heart failure causes sodium levels to increase, which in turn leads to the body retaining more fluid. Sequana Medical\u2019s DSR therapy involves the removal of sodium via diffusion from the<br \/>\nperitoneal cavity by administering a sodium-free solution (the infusate) into the abdomen. The infusate and the extracted sodium are then removed, resulting in the elimination of sodium from the body. The<br \/>\nbody responds by eliminating the associated fluid via osmotic ultrafiltration and\/or urination.<\/p>\n<p>The impact of administering a sodium-free infusate to the peritoneal cavity, and the resulting sodium and fluid removal, was evaluated in a preclinical study with 20 pigs, of which five had experimentally<br \/>\ninduced heart failure. The study demonstrated that DSR therapy is capable of removing large quantities of fluid and sodium whilst having a negligible impact on the sodium concentration in the bloodstream,<br \/>\nindicating the potential of this therapeutic approach.<\/p>\n<p>The findings of the study were presented by Principal Investigator Jeffrey Testani, MD MTR, Associate Professor, Yale University at the 22nd Annual Scientific Meeting of HFSA being held from 15-18<br \/>\nSeptember in Nashville, Tennessee. The poster will be made available on the Sequana Medical website, under the news &amp; events section.<\/p>\n<p><strong>Dr. Jeffrey Testani, Associate Professor at Yale University, commented:<\/strong>\u00a0\u201cVolume overload in heart failure is a major clinical challenge in the significant proportion of patients that no longer respond effectively to diuretic therapy. The concept of sodium and fluid removal via non-renal routes is an interesting approach given the limitations of existing therapies. These results show that by administering a relatively small volume of a sodium-free solution, DSR therapy can remove a clinically relevant amount of sodium and fluid.\u201d<\/p>\n<p><strong>Ian Crosbie, Chief Executive Officer of Sequana Medical, added:<\/strong>\u00a0\u201cObtaining proof of concept in this preclinical study is an important step in the further development of DSR therapy and first in human studies are planned for later this year. Through leveraging our proven <strong>alfa<\/strong>pump\u00ae platform, we are developing the <strong>alfa<\/strong>pump\u00ae DSR system to deliver a convenient and fully implanted system for DSR therapy and intend to commence first in human studies with the system in the second half of 2019.\u201d<\/p>\n<p>&nbsp;<\/p>\n<p><strong>CONTACTS<\/strong><\/p>\n<p><strong>Sequana Medical AG<\/strong><br \/>\nLies Vanneste<br \/>\nDirector IR<br \/>\n+32 (0) 498 05 35 79<br \/>\n<a href=\"mailto:IR@sequanamedical.com\">IR@sequanamedical.com<\/a><\/p>\n<p><strong>Consilium Strategic Communications<\/strong><br \/>\nAmber Fennell, Alexandra Harrison, Sukaina Virji<br \/>\nDirector IR<br \/>\n+44 (0) 203 709 5000<br \/>\n<a href=\"mailto:sequanamedical@consilium-comms.com\">sequanamedical@consilium-comms.com<\/a><\/p>\n<p>&nbsp;<br \/>\n__<\/p>\n<p><strong>ENDS<br \/>\nNote to Editors<br \/>\nAbout Heart Failure<\/strong><\/p>\n<p>Volume overload in heart failure is a major clinical problem. There are 6.5 million adults in the U.S. suffering from heart failure and this number is forecasted to grow to 8.0 million by 2030. There are over one million hospitalisations in the United States (the \u201cU.S.\u201d) each year due to heart failure and 90% are due to symptoms of volume overload. The treatment options are severely limited in those patients for whom diuretic therapy is no longer effective. This limitation is evident from the 24% hospital re-admission rate at 30 days from discharge. The estimated cost of heart failure-related hospitalisations in the U.S. is $13 billion a year.<\/p>\n<p><strong>About Sequana Medical<\/strong><\/p>\n<p>Sequana Medical is a commercial stage medical device company focused on the development of innovative treatment solutions for the management of liver disease, heart failure, malignant ascites and other fluid imbalance disorders.<\/p>\n<p>Sequana Medical\u2019s\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0is a fully implantable, programmable, wirelessly-charged, battery-powered system that is CE-marked for the management of i) refractory ascites (chronic fluid build-up in the abdomen) due to liver cirrhosis and ii) malignant ascites (with a life expectancy of six months or less). The number of patients with liver refractory ascites is forecast to increase dramatically due to the growing prevalence of NASH (Non-alcoholic Steatohepatitis).<\/p>\n<p>Over 650\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0systems have been implanted and since April 2018, the\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0has been included in the EASL (European Association for the Study of the Liver) clinical practice guidelines for decompensated cirrhosis. The\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0MOSAIC North American IDE feasibility study in patients with liver refractory or recurrent ascites is complete and initial results were presented at the AASLD (American Association for the Study of Liver Diseases) in October 2017. The\u00a0<strong>alfa<\/strong>pump<sup>\u00ae\u00a0<\/sup>has not yet received a pre-market approval\u00a0in the U.S.<\/p>\n<p>The\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0is one of the first safe and effective, long-term alternatives to large-volume paracentesis which is a lengthy, invasive and painful procedure, only providing short-term symptomatic relief, requiring hospital visits and placing a significant burden on the healthcare system and patient quality of life. By automatically and continuously moving ascites to the bladder, where the body eliminates it naturally through urination, the\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0prevents fluid build-up and its possible complications, improving patient quality of life and nutrition, and potentially reducing hospital visits and healthcare costs. The\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0DirectLink technology allows clinicians to receive pump performance information and more effectively manage patients treated by the\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>.<\/p>\n<p>Sequana Medical is developing the\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0DSR, built upon the proven\u00a0<strong>alfa<\/strong>pump<sup>\u00ae<\/sup>\u00a0platform, to deliver a convenient and fully implanted system for DSR therapy, a novel and proprietary approach for the management of fluid overload in heart failure. Data from animal studies presented at EuroPCR 2018 and HFSA 2018 indicate that DSR therapy is effective and safe.<\/p>\n<p>Sequana Medical is headquartered in Zurich, Switzerland and investors include NeoMed Management, Life Science Partners, VI Partners, BioMedPartners, Capricorn Venture Partners, Entrepreneur\u2019s Fund and Salus Partners.\u00a0 For further information, please visit www.sequanamedical.com<\/p>\n<p>Download the full\u00a0<a href=\"\/wp-content\/uploads\/2018\/09\/Press-release_DSR-preclin-data-HFSA-meeting_17-Sept-2018.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">press release<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zurich, SWITZERLAND \u2013 17 September 2018 \u2013 Sequana Medical AG (\u201cSequana Medical\u201d), a commercial stage medical device company focused on the development of innovative treatment solutions for the management of liver disease, heart failure, malignant ascites and other fluid imbalance disorders, announces today positive findings from its Direct Sodium Removal (\u201cDSR\u201d) therapy proof of concept [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[74],"tags":[94],"class_list":["post-5158","post","type-post","status-publish","format-standard","hentry","category-persberichten","tag-niet-gereglementeerd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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