{"id":18187,"date":"2024-06-06T10:03:43","date_gmt":"2024-06-06T08:03:43","guid":{"rendered":"https:\/\/www.sequanamedical.com\/geen-onderdeel-van-een-categorie\/sequana-medical-announces-data-on-alfapump-safety-and-quality-of-life-to-be-presented-at-easl-congress-2024\/"},"modified":"2024-06-06T10:20:00","modified_gmt":"2024-06-06T08:20:00","slug":"sequana-medical-announces-data-on-alfapump-safety-and-quality-of-life-to-be-presented-at-easl-congress-2024","status":"publish","type":"post","link":"https:\/\/www.sequanamedical.com\/nl\/persberichten\/sequana-medical-announces-data-on-alfapump-safety-and-quality-of-life-to-be-presented-at-easl-congress-2024\/","title":{"rendered":"Sequana Medical announces data on alfapump\u00ae safety and quality of life to be presented at EASL Congress 2024"},"content":{"rendered":"\n

PRESS RELEASE<\/strong><\/p>\n\n\n\n

REGULATED INFORMATION<\/strong><\/p>\n\n\n\n

6 JUNE, 2024, 07.00 CEST<\/u><\/strong><\/p>\n\n\n\n


<\/p>\n\n\n\n

Sequana Medical announces data on alfapump<\/strong>\u00ae<\/strong> <\/strong>safety and quality of life to be <\/strong>presented a<\/strong>t EASL Congress 2024<\/strong><\/p>\n\n\n\n

\u201calfapump implantation significantly improved quality of life and showed similar safety outcomes compared to a contemporaneously enrolled refractory ascites cohort\u201d;
oral poster presentation by Dr. Bajaj<\/em><\/strong><\/p>\n\n\n\n

Matched cohort analysis of patients from North American pivotal alfapump study (POSEIDON) vs. contemporaneous NACSELD3 study<\/em><\/strong><\/p>\n\n\n\n

Strong commercial positioning for alfapump; US launch planned for H2 2025<\/em><\/strong><\/p>\n\n\n\n

Ghent, Belgium \u2013 6 June 2024<\/strong> \u2013 <\/strong>Sequana Medical NV <\/strong>(Euronext Brussels: SEQUA) <\/strong>(the “Company<\/strong>” or “Sequana<\/strong> Medical<\/strong>“), a pioneer in the treatment of fluid overload in liver disease, heart failure and cancer, today announces data from its North American pivotal POSEIDON study of the alfa<\/strong>pump\u00ae<\/em> demonstrating significantly improved quality of life focused on ascites symptoms and physical functions compared to baseline, which is not seen in refractory ascites patients enrolled contemporaneously in the prospective NACSELD3 (North American Consortium for Study of End-Stage Liver Disease) cohort.  The two cohorts were matched for Ascites-Q, age, sex and enrolment MELD-NA, which is a scoring system for assessing the severity of chronic liver disease.  These data will be presented as an oral poster presentation on Friday 7th June 2024 at  09.30am CEST at the EASL Congress 2024<\/a>, Europe\u2019s largest event in this domain, taking place in Milan, Italy.<\/p>\n\n\n\n

Dr. Bajaj, Professor of Medicine at Virginia Commonwealth University and Richmond VA Medical<\/strong> Center<\/strong> commented:<\/strong> \u201cA real-world, propensity-matched North American cohort of patients which was matched to the POSEIDON study showed significantly improved quality of life with the alfa<\/strong>pump.  This could help this unmet need in patients with cirrhosis and recurrent or refractory ascites.\u201d<\/em><\/p>\n\n\n\n

Dr. Gijs Klarenbeek, MD, Chief Medical Officer at Sequana Medical, added: <\/strong>\u201cThis important study adds to the existing evidence from controlled studies and real world evidence. All data consistently shows the impact of the alfa<\/strong>pump on quality of life for this patient population, underserved by current therapeutic options. At Sequana Medical, we are focused on bringing the alfa<\/strong>pump to physicians, patients and their caregivers as they deserve modern and impactful care for this condition that has such a detrimental effect on how they live their lives.\u201d<\/em><\/p>\n\n\n\n

Matched cohort analysis of 37 patients from each study<\/strong><\/a><\/p>\n\n\n\n

This was a comparative analysis in which 37 patients from the North Americal pivotal alfa<\/strong>pump study (POSEIDON) were matched 1:1 to patients from the NACSELD3 prospective cirrhosis cohort.<\/p>\n\n\n\n

For the alfa<\/strong>pump cohort, Quality of Life (as evaluated by Ascites-Q and SF-36 (Physical Component Score)) improved significantly at six months compared to baseline, but this benefit was not seen in the NACSELD3 cohort.<\/p>\n\n\n\n

There was no statistically significant difference in mortality, hospitalisations or liver transplants between the two groups; the hospitalisations in the POSEIDON group were mainly observed in the post-implant period.<\/p>\n\n\n\n

 <\/td>POSEIDON (n=37)<\/strong><\/td>NACSELD3 (n=37)<\/strong><\/td>P-value<\/strong><\/td><\/tr>
Deaths<\/strong><\/td>10.8% (4\/37)<\/td>10.8% (4\/37)<\/td> <\/td><\/tr>
Hospitalisations<\/strong><\/td>45.9% (17\/37)<\/td>35.1 (13\/37)<\/td>0.48<\/td><\/tr>
Liver Transplant<\/strong><\/td>5.4% (2\/37)<\/td>8.1% (3\/37)<\/td>1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

— END —<\/strong><\/p>\n\n\n\n

For more information, please contact:<\/strong><\/p>\n\n\n\n

Sequana Medical<\/strong><\/p>\n\n\n\n

Ian Crosbie, CEO<\/p>\n\n\n\n

E: IR@sequanamedical.com<\/a><\/p>\n\n\n\n

T: +44 7973 42 99 17<\/p>\n\n\n\n

About alfapump in recurrent or refractory ascites due to liver cirrhosis<\/strong><\/p>\n\n\n\n

Recurrent or refractory ascites is a severe condition characterized by the accumulation of fluid in the abdomen. The current standard treatment involves therapeutic paracentesis, an invasive and burdensome procedure that drains ascites from the abdomen using a large needle over an extended period. If approved by the FDA, the alfa<\/strong>pump could become the first active implantable medical device in the US that automatically and continuously removes ascites from the abdomen into the bladder, where it is naturally eliminated through urination.<\/p>\n\n\n\n

The PMA application submitted to the US FDA was based on the successful execution of Sequana Medical\u2019s pivotal POSEIDON study, a landmark study across 18 centers in the US and Canada with a total of 69 patients implanted with the alfa<\/strong>pump. The primary effectiveness endpoints at six months post-implantation in the Pivotal Cohort[i]<\/a> exceeded the predefined thresholds with statistical significance, and primary safety endpoint data was in line with expectations[ii]<\/a>. Data at 12 months post-implantation continued to show a strong and durable clinical profile, virtually eliminating the need for therapeutic paracentesis and delivering a clinically meaningful improvement in patients\u2019 quality of life[iii]<\/a>. <\/p>\n\n\n\n

Data from the patient preference study and a matched cohort analysis of the NACSELD-III registry with the POSEIDON Pivotal Cohort indicated that US patients have a strong preference for the alfa<\/strong>pump vs standard paracentesis procedures and that the safety profile of the alfa<\/strong>pump is comparable to standard of care.<\/p>\n\n\n\n

The North American market of recurrent and refractory ascites due to liver cirrhosis is forecast to grow on average 9% per year, from approximately 78,000 patients in 2025 reaching 147,000 patients by 2032, primarily driven by the increasing prevalence of NASH[iv]<\/a>. The total market opportunity for alfa<\/strong>pump is estimated at $2.4 billion in 2025, including approximately $600 million from the Company\u2019s initial priority market targeting patients requiring at least 12 paracenteses per year. To date, over 1,000 alfa<\/strong>pump systems have been implanted.<\/p>\n\n\n\n

About Sequana Medical<\/strong><\/p>\n\n\n\n

Sequana Medical NV is a pioneer in treating fluid overload, a serious and frequent clinical complication in patients with liver disease, heart failure and cancer. This causes major medical issues including increased mortality, repeated hospitalizations, severe pain, difficulty breathing and restricted mobility. Although diuretics are standard of care, they become ineffective, untolerable or exacerbate the problem in many patients. There are limited effective treatment options, resulting in poor clinical outcomes, high costs and a major impact on their quality of life. Sequana Medical is seeking to provide innovative treatment options for this large and growing “diuretic-resistant” patient population. alfa<\/strong>pump\u00ae and DSR\u00ae are Sequana Medical’s proprietary platforms that work with the body to treat diuretic-resistant fluid overload, delivering major clinical and quality of life benefits for patients and reducing costs for healthcare systems.<\/p>\n\n\n\n

The Company’s Premarket Approval (PMA) application for the alfa<\/strong>pump was submitted to the US FDA in December 2023 and accepted for substantive review in January 2024, having reported positive primary and secondary endpoint data from the North American pivotal POSEIDON study in recurrent or refractory ascites due to liver cirrhosis.  US market approval of the alfa<\/strong>pump is anticipated before the end of Q1 2025 with US commercial launch planned for H2 2025.<\/p>\n\n\n\n

Results of the Company’s RED DESERT and SAHARA proof-of-concept studies in heart failure support DSR’s mechanism of action as breaking the vicious cycle of cardiorenal syndrome. All three patients from the non-randomized cohort of MOJAVE, a US randomized controlled multi-center Phase 1\/2a clinical study, have been successfully treated with DSR, resulting in a dramatic improvement in diuretic response and virtual elimination of loop diuretic requirements. The independent Data Safety Monitoring Board approved the start of the randomized MOJAVE cohort of up to a further 30 patients, which is planned after alfa<\/strong>pump US PMA approval.<\/p>\n\n\n\n

Sequana Medical is listed on the regulated market of  Euronext Brussels (Ticker: SEQUA.BR) and headquartered in Ghent, Belgium. For further information, please visit www.sequanamedical.com<\/a>.<\/p>\n\n\n\n

Important Regulatory Disclaimers<\/em><\/strong><\/p>\n\n\n\n

The alfa<\/strong>pump\u00ae system is currently not approved in the United States or Canada. In the United States and Canada, the alfa<\/strong>pump system is currently under clinical investigation (POSEIDON Trial) and is being studied in adult patients with refractory or recurrent ascites due to liver cirrhosis. DSR\u00ae therapy is still in development and it should be noted that any statements regarding safety and efficacy arise from ongoing pre-clinical and clinical investigations which have yet to be completed. There is no link between DSR therapy and ongoing investigations with the alfa<\/strong>pump system in Europe, the United States or Canada.<\/em><\/p>\n\n\n\n

Note: alfa<\/strong>pump\u00ae and DSR\u00ae are registered trademarks.<\/em><\/p>\n\n\n\n

<\/a>Forward-looking statements<\/em><\/strong><\/em><\/strong><\/p>\n\n\n\n

<\/a>This press release may contain predictions, estimates or other information that might be considered forward-looking statements.<\/em><\/p>\n\n\n\n

Such forward-looking statements are not guarantees of future performance. These forward-looking statements represent the current judgment of Sequana Medical on what the future holds, and are subject to risks and uncertainties that could cause actual results to differ materially. Sequana Medical expressly disclaims any obligation or undertaking to release any updates or revisions to any forward-looking statements in this press release, except if specifically required to do so by law or regulation. You should not place undue reliance on forward-looking statements, which reflect the opinions of Sequana Medical only as of the date of this press release.<\/em><\/p>\n\n\n\n

\n\n\n\n

[i]<\/a> The Pivotal Cohort is used for the primary effectiveness endpoints and consists of 40 patients implanted with the alfa<\/strong>pump<\/p>\n\n\n\n

[ii]<\/a> Data reported in press release of 25 October 2022<\/a><\/p>\n\n\n\n

[iii]<\/a> Data reported in press release of 19 October 2023<\/a><\/p>\n\n\n\n

[iv]<\/a> Based on US and Canada market assessment conducted by highly experienced international consulting group<\/p>\n\n\n\n

<\/p>\n\n\n\n


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